E350 — Hybrid · RWD · 2L 4-cyl · 28 MPG
2025 Mercedes-Benz E-Class
Compare 5 EPA-tested configurations, including the exact powertrain, fuel, driven wheels, engine, transmission and efficiency data available for this model year.
Choose the closest tested configuration.
These entries distinguish powertrains and driveline combinations recorded by the U.S. EPA. They help narrow the vehicle, but they are not guaranteed retail trim or option-package names.
- Fuel
- Premium and Electricity
- Engine
- SIDI; PHEV · turbocharged
- Drive
- AWD
- Transmission
- Automatic 9-spd
- EPA combined
- 23 MPG combined
- City / highway
- 21 / 26 MPG
- Electric motor
- 120 kW AC PMSM
- Range
- 43 mi electric · 410 mi total
- 240 V charge time
- 2.75 hours
- Secondary / blended economy
- 59 MPGe secondary fuel · 39 MPGe blended
- EPA vehicle class
- Midsize Cars
- Stop-start system
- No
AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG selected.
Configuration is not the same as trim. EPA records can separate engines, fuel systems, transmissions or driven wheels without identifying badges such as LX, XLE or Touring. Confirm the retail trim with the window sticker, build sheet or manufacturer VIN portal.
Mechanical and efficiency differences.
All rows are visible in the page and link to their exact government record. EPA configurations identify tested hardware, not guaranteed retail trim names.
AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG
View all 5 EPA configuration rows
| EPA carline | Powertrain | Engine / motor | Drive | Transmission | Combined | Range / charge | Source |
|---|---|---|---|---|---|---|---|
| AMG E53 Hybrid 4matic Plus — Plug-in hybrid · AWD · 3L 6-cyl · 23 MPG | Plug-in hybridPremium and Electricity | SIDI; PHEV | AWD | Automatic 9-spd | 23 MPG21 city / 26 highway | 43 mi EV / 410 mi total2.75 h at 240 V | EPA record ↗ |
| E350 — Hybrid · RWD · 2L 4-cyl · 28 MPG | HybridPremium | SIDI; Mild Hybrid | RWD | Automatic 9-spd | 28 MPG25 city / 33 highway | — | EPA record ↗ |
| E350 4matic — Hybrid · AWD · 2L 4-cyl · 27 MPG | HybridPremium | SIDI; Mild Hybrid | AWD | Automatic 9-spd | 27 MPG24 city / 33 highway | — | EPA record ↗ |
| E450 4matic — Hybrid · AWD · 3L 6-cyl · 25 MPG | HybridPremium | SIDI; Mild Hybrid | AWD | Automatic 9-spd | 25 MPG22 city / 31 highway | — | EPA record ↗ |
| E450 4matic All-Terrain (wagon) — Hybrid · AWD · 3L 6-cyl · 25 MPG | HybridPremium | SIDI; Mild Hybrid | AWD | Automatic 9-spd | 25 MPG22 city / 31 highway | — | EPA record ↗ |
What the official records cover.
Each option above is tied to a unique FuelEconomy.gov vehicle ID. EPA names sometimes expose a retail badge such as LE or Woodland Edition, but many records identify only the tested mechanical configuration.
AMG E53 Hybrid 4matic Plus, E350, E350 4matic, E450 4matic, E450 4matic All-Terrain (wagon)
Plug-in hybrid, Hybrid
AWD, RWD
3L 6-cyl, 2L 4-cyl
Match the hardware before the badge.
- 1
Start with fuel and powertrain. Check whether the vehicle is gasoline, diesel, hybrid, plug-in hybrid, electric or fuel-cell.
- 2
Match driven wheels and engine. Use FWD, RWD, AWD or 4WD plus displacement/cylinder information from the window sticker or registration.
- 3
Confirm the exact EPA record. Select the closest option and open its FuelEconomy.gov link. Use a VIN-specific build sheet when you need the retail trim or option package.
Source: U.S. Department of Energy / EPA FuelEconomy.gov dataset ↗ · U.S. market snapshot 2026-11-04. Economy values are official estimates, not a promise of real-world consumption.
The configuration guide is live.
The official mechanical and efficiency data for this exact vehicle is published above. Hidden-feature instructions are a separate layer: they appear only after the correct owner manual, model-year scope and equipment caveats have been checked.